Changing Role of HRM Essay Example | Topics and Well Written Essays - 3250 words

Changing Role of HRM - Essay Example This essay explores the functions of HR department within a company and the changing role it performs nowadays. Humans have always been a critical resource for almost all organizations for a greater or lesser extent. They are diverse, necessary and at times problematic as well. Talented and capable employees are the foundation stone of a competitive edge for most organizations. Since 1900, the field of Human Resource Management has gone forward a great deal. Initially, it was only about the clerical operations of an organization and activities such as payroll, employee records and arrangement of community trips. Until 1960s and 1970s, these activities stayed under the umbrella of Personnel Development, however with the social legislations that passed in these years striking changes modified the organizational element of human resource. With great inclination towards globalization, competitions, mergers as well as acquisitions in 1990s, there was an increase in concern for costs, plan ning and implementation of strategies for both organization as well as its employees, finally compelling a structured development of a Human Resource Department. With the changing trend, the empowering of HR department is elevating. From the very basic to the very top, HR performs four different roles today. These are the roles as administrator, employee advocate, operational and strategic. While the administrative role focuses largely on the secretarial and clerical supervision, employee advocate role aims to serve as a morale officer.

Role Of Notch Signaling In Oncogenesis Essay Example | Topics and Well Written Essays - 2250 words

Role Of Notch Signaling In Oncogenesis - Essay Example Extensive research in notch pathway has identified either dysregulation or faulty signaling in cancers and many other diseases like multiple sclerosis, tetralogy of Fallot and Alagille syndrome. Because Notch signaling pathway is involved in the progression and development of several malignancies, it is considered a novel therapeutic target and if the research on this aspect is fruitful, it can have the highest therapeutic impact in modern clinical medicine (Wang, Li, Banerjee and Sarkar, 2008).The Notch signaling pathway The most important constituents of the Notch signaling pathway are the receptors. There are basically four types of Notch receptors which are single- pass transmembrane receptor proteins. They are Notch1 through Notch 4. Each of these is a heterodimer which is proteolytically cleaved and lies at the surface of the cell. The receptor is made up of 2 domains, the ectodomain and intracellular domain. Both these domains are associated in a calcium dependent, noncovalent interaction. Ectodomain is large and constitutes the outside part of the cell surface. The intracellular domain is smaller and tethered to the membrane. The ectodomain part of Notch receptors interacts with certain ligands of adjacent cells. These ligands belong to Jagged and Delta- like families and are named as JAG1, JAG2, DLL1, DLL3, and DLL4. The interaction between the receptor and ligand induces a couple of proteolytic cleavages causing the release of the intracellular domain part of the receptor from the cell membrane.